常规超声与超声造影对鉴别诊断肝脏神经内分泌肿瘤的临床价值

摘要/Abstract

摘要： 目的探讨超声与超声造影对鉴别诊断肝脏神经内分泌肿瘤(HNET)的临床价值。方法纳入128例肝脏疾病患者作为研究对象, 其中肝细胞肝癌(HCC)89例, HNET患者39例。记录两组患者超声和超声造影影像特点, 比较两组患者超声造影增强时间, MHNET与PHNET超声与超声造影影像特点, 以及超声造影增强时间。结果超声检查显示HNET组单发病灶12例, 低于HCC组的68例;两组回声情况、后方回声减弱、回声均匀比较, 差异均有统计学意义(P<0.05)。超声造影显示HNET组包膜增强4例, 占比低于HCC组, 差异有统计学意义(P<0.05)。HNET组患者消退为等增强和低增强时间分别为(31.64±10.27)s和(64.82±16.85)s, 显著短于HCC组的(38.44±11.95)s和(80.31±20.79)s(P<0.05)。超声检查显示MHNET病灶最大径为(4.47±1.89)cm, 显著低于PHNET的(10.12±4.35)(P<0.05)。结论超声与超声造影检查有助于HNET的筛查, 为MHNET与PHNET鉴别诊断提供依据。

关键词: 超声, 肝脏神经内分泌肿瘤, 肝细胞肝癌, 鉴别诊断

Abstract: Objective To study the application value of ultrasound and contrast-enhanced ultrasound in differential diagnosis of hepatic neuroendocrine tumors (HNET).Methods 128 patients with liver diseases were as the research objectors, 89 cases of hepatocellular carcinoma (HCC) were in the control group, 39 cases of HNET were in the observation group among them.Meanwhile, the image characteristics of conventional ultrasound and contrast-enhanced ultrasound were recorded, and the contrast-enhanced time was compared between the two groups.The imaging characteristics of MHNET and PHNET ultrasound and contrast-enhanced ultrasound were recorded, and the contrast-enhanced time of two groups of patients were compared.Results The ultrasonography showed that there were 12 cases of single focus in the observation group were lower than 68 cases in the control group, there were 19 cases of hyperechoic imaging, 8 cases of hypoechoic imaging, 28 cases of homogeneous imaging, the proportion were higher thanthose of the control group, the difference were statistically significant (P<0.05).The contrast-enhanced ultrasound showed that the capsule of the observation group was enhanced in 4 cases, the proportion was lower than that of the control group, the difference was statistically significant (P<0.05).The time of regression to isoenhancement and the time of hypoenhancement in the observation group were (31.64±6.38) s and (64.82±16.85) s respectively, which were significantly shorter than those of the control group (P<0.05).The maximum diameter of MHNET lesions were (4.47±1.89) cm, which were significantly lower than that of PHNET (P<0.05).Conclusion The ultrasound and contrast-enhanced ultrasound are helpful for screening of HNET, and it can provide basis for differential diagnosis between MHNET and PHNET.

Key words: Color doppler ultrasound, Hepatic neuroendocrine tumors, Hepatocellular carcinoma, Differential diagnosis

木合塔江·吾布利哈斯木, 古再努尔·阿吉木, 穆塔力甫. 常规超声与超声造影对鉴别诊断肝脏神经内分泌肿瘤的临床价值[J]. 肝脏, 2020, 25(6): 598-601.

Muhetajiang·Wubulihasimu, Guzainuer·A jimu, Mutalifu. The value of conventional ultrasound and contrast-enhanced ultrasound in diagnosis and differentiation of hepatic neuroendocrine tumors[J]. Chinese Hepatolgy, 2020, 25(6): 598-601.

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