原发性肝癌患者术后外周血T淋巴细胞亚群及NK细胞水平与复发转移的相关性

肝脏 ›› 2021, Vol. 26 ›› Issue (2): 171-174.

原发性肝癌患者术后外周血T淋巴细胞亚群及NK细胞水平与复发转移的相关性

何清, 李阳, 姜里航, 邓盼盼, 刘伟, 缪宇飞

214000 江苏无锡联勤保障部队第九○四医院无锡院区检验科(何清,姜里航,邓盼盼,刘伟,缪宇飞);无锡市中医医院检验科(李阳)

收稿日期:2020-04-03 出版日期:2021-02-28 发布日期:2021-03-28
通讯作者: 李阳,Email:121400990@qq.com

The relation of peripheral blood levels of T lymphocyte subsets and NK cell to recurrence and metastasis in patients with primary liver cancer after operation

HE Qing¹, LI Yang², JIANG Li-hang¹, DENG Pan-pan¹, LIU Wei¹, LIAO Yu-fei¹

1. Department of Clinical Laboratory, Wuxi District, No 904 Hospital of Chinese People's Liberation Army,Wuxi 214000, China;
2. Department of Clinical Laboratory,Wuxi Traditional Chinese Medicine Hospital, Jiangsu 214000, China

Received:2020-04-03 Online:2021-02-28 Published:2021-03-28
Contact: LI Yang,Email:121400990@qq.com

摘要/Abstract

摘要： 目的分析外周血T淋巴细胞亚群、同种异体自然杀伤细胞(NK)水平与原发性肝癌患者复发转移的关系。方法回顾分析,选择2017年3月至2019年3月期间接受肝切除术治疗的58例原发性肝癌患者作为研究对象,根据患者术后随访复发情况将其分为复发转移组(21例)与未复发转移组(37例)。采集各患者外周血,检测并比两组患者T淋巴细胞亚群各指标及NK细胞水平;行回归分析检验各指标对复发转移的影响。结果复发转移组CD₃⁺、CD₃⁺/CD₄⁺、NK细胞表达均低于未复发转移组,CD₃⁺/CD₈⁺表达高于未复发转移组,差异有统计学意义(P<0.05);CD₃⁺与原发性肝癌患者术后复发转移无关,CD₃⁺/CD₄⁺、CD₃⁺/CD₈⁺、NK细胞水平变化可能是原发性肝癌患者复发转移的影响因素(P<0.05)。结论原发性肝癌患者机体存在不同程度免疫功能紊乱,这种免疫功能紊乱可能与患者术后复发转移有关,也可能是复发转移的影响因素,应引起临床重视。

关键词: 原发性肝癌, 根治术, 复发转移, 外周血T淋巴细胞亚群, NK细胞, 相关性

Abstract: Objective To analyze the correlation of peripheral blood levels of T lymphocyte subsets and natural killer (NK) cell with recurrence and metastasis in primary liver cancer patients after operation.Methods The retrospective analysis was performed. Fifty-eight patients with primary liver cancer undergoing hepatectomy in our hospital from March 2017 to March 2019 were enrolled. All patients were divided into a recurrence and metastasis group (21 cases) and a non-recurrence and metastasis group (37 cases) according to postoperative follow-up. The peripheral blood of patients was collected, and the levels of T lymphocyte subsets and NK cell of the 2 groups were detected and compared. The regression analysis was performed to analyze the correlation of each index with recurrence and metastasis. Results The levels of CD₃⁺, CD₃⁺/CD₄⁺, NK cell in recurrence and metastasis group were lower than those in non-recurrence and metastasis group, and the level of CD₃⁺/CD₈⁺ in recurrence and metastasis group was higher than that in non-recurrence and metastasis group (P<0.05). CD₃⁺ level had no relation to postoperative recurrence and metastasis in patients with primary liver cancer. The levels of CD₃⁺/CD₄⁺, CD₃⁺/CD₈⁺ and NK cell may be the influencing factors for recurrence and metastasis (P<0.05).Conclusion Patients with primary liver cancer have immune dysfunction in different degrees. The immune dysfunction may be related to the postoperative recurrence and metastasis, which deserves clinical attention.

Key words: Primary liver cancer, Radical resection, Recurrence and metastasis, Peripheral blood T lymphocyte subsets, Natural killer cell, Correlation

何清, 李阳, 姜里航, 邓盼盼, 刘伟, 缪宇飞. 原发性肝癌患者术后外周血T淋巴细胞亚群及NK细胞水平与复发转移的相关性[J]. 肝脏, 2021, 26(2): 171-174.

HE Qing, LI Yang, JIANG Li-hang, DENG Pan-pan, LIU Wei, LIAO Yu-fei. The relation of peripheral blood levels of T lymphocyte subsets and NK cell to recurrence and metastasis in patients with primary liver cancer after operation[J]. Chinese Hepatolgy, 2021, 26(2): 171-174.

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