水隔离技术用于原发性肝癌MWA治疗对患者3年预后的影响

肝脏 ›› 2021, Vol. 26 ›› Issue (5): 527-529.

水隔离技术用于原发性肝癌MWA治疗对患者3年预后的影响

王闯胜, 孙婕, 石佳

467099 河南平顶山平煤神马医疗集团总医院介入放射科(王闯胜,石佳),超声科(孙婕)

收稿日期:2020-10-23 出版日期:2021-05-31 发布日期:2021-06-17
通讯作者: 王闯胜,Email:cici33654@126.com
基金资助:
河南省医学科技攻关计划项目(201702338)

Effect of water isolation technology in MWA treatment for primary liver cancer on the 3-year prognosis of patients

WANG Chuang-sheng¹, SUN Jie², SHI Jia¹

Pingmei Shenma Medical Group General Hospital (1. Department of Interventional Radiology, 2. Department of Ultrasound), Pingdingshan 467099, China

Received:2020-10-23 Online:2021-05-31 Published:2021-06-17
Contact: WANG Chuang-sheng,Email:cici33654@126.com

摘要/Abstract

摘要： 目的研究水隔离技术用于原发性肝癌(PLC)经皮微波消融(MWA)治疗对患者3年预后的影响。方法选取平煤神马医疗集团总医院2019年7月至2020年收治的108例PLC患者纳入研究对象,依据治疗方式的不同分为水隔离+MWA组(n=55)、MWA组(n=53)。MWA组行MWA治疗,水隔离+MWA组行MWA治疗的同时使用水隔离技术。对比两组临床疗效及术后并发症发生情况,对比两组治疗前后血清丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、肿瘤相关黏液抗原(CA242)、糖链抗原19-9(CA19-9)水平差异,最后对两组患者行3年院外随访,统计两组患者3年生存率。结果水隔离+MWA组有效率、疾病控制率显著高于MWA组(85.45%、94.55% VS 69.81%、81.13%,P<0.05)。水隔离+MWA组治疗后各项血清指标显著低于治疗前及MWA组治疗后,P<0.05。两组并发症总发生率比较无显著差异(7.27% VS 11.32%,P>0.05)。两组均行3年随访,随访期间水隔离+MWA组失访6例,3年生存率67.35%(33/49),MWA组失访5例,3年生存率41.67%(20/48),两组生存率比较(Log Rank=0.004)。结论 PLC患者行MWA治疗时使用水隔离技术能够提高临床治疗效果,并改善患者远期预后。

关键词: 原发性肝癌, 经皮微波消融, 水隔离, 疗效, 预后

Abstract: Objective To investigate the impact of water isolation technology in percutaneous microwave ablation (MWA) in the treatment for primary liver cancer (PLC) on the 3-year prognosis of patients.Methods One hundred and eight PLC patients admitted to our hospital from July 2019 to 2020 were included and divided into 2 groups according to different treatment methods. The MWA group (n=55) was treated with MWA, and the water isolation + MWA group (n=53) was treated with MWA combined with water isolation technology. The clinical efficacy and postoperative complications were compared between 2 groups. The levels of serum alanine aminotransferase, aspartate aminotransferase, carbohydrate antigen 242 and carbohydrate antigen 19-9 were compared before and after treatment in 2 groups. Moreover, the patients were followed up for 3 years after discharging from hospital, and the 3-year survival rate of the 2 groups was calculated.Results The effective rate and disease control rate of the water isolation + MWA group were significantly higher than those of the MWA group (85.45%, 94.55% vs 69.81%, 81.13%, P<0.05). The serum indexes of the water isolation + MWA group after treatment were significantly lower than those before treatment (P<0.05), and significantly lower than those after treatment in the MWA group (P<0.05). There was no significant difference in the incidence of complications between the 2 groups (7.27% vs 11.32%, P>0.05). During the 3-year follow-up period, 6 patients in the water isolation + MWA group and 5 patients in the MWA group were lost. The 3-year survival rate of the water isolation + MWA group and the MWA group were 67.35% (33/49) and 41.67% (20/48), respectively, and there were statistical differences between 2 groups (P=0.004).Conclusion Water isolation technology in MWA treatment can improve clinical treatment efficacy and long-term prognosis of PLC patients.

Key words: Primary liver cancer, Percutaneous microwave ablation, Water isolation, Curative effect, Prognosis

王闯胜, 孙婕, 石佳. 水隔离技术用于原发性肝癌MWA治疗对患者3年预后的影响[J]. 肝脏, 2021, 26(5): 527-529.

WANG Chuang-sheng, SUN Jie, SHI Jia. Effect of water isolation technology in MWA treatment for primary liver cancer on the 3-year prognosis of patients[J]. Chinese Hepatolgy, 2021, 26(5): 527-529.

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