合并巨细胞病毒感染对小儿乙型肝炎疫苗初次免疫应答的影响

肝脏 ›› 2021, Vol. 26 ›› Issue (5): 554-556.

合并巨细胞病毒感染对小儿乙型肝炎疫苗初次免疫应答的影响

叶明, 徐璐, 赵子华, 段双霞

453000 河南新乡市疾病预防控制中心(叶明,徐璐,赵子华);
新乡市中心医院(段双霞)

收稿日期:2020-11-07 出版日期:2021-05-31 发布日期:2021-06-17
通讯作者: 叶明,Email:x4t5h6@163.com
基金资助:
河南省新乡市科技攻关计划项目(CXGG16058)

Effect of cytomegalovirus infection on primary immune response to hepatitis B vaccine in infants

YE Ming¹, XU Lu¹, ZHAO Zi-hua¹, DUAN Shuang-xia²

1. Xinxiang CDC, Henan 453000, China;
2. Xinxiang Central Hospital, Henan 453000, China

Received:2020-11-07 Online:2021-05-31 Published:2021-06-17
Contact: YE Ming,Email:x4t5h6@163.com

摘要/Abstract

摘要： 目的研究合并巨细胞病毒(HCMV)感染对小儿乙肝疫苗初次免疫应答的影响。方法选取新乡市中心医院2017年1月至2018年1月148例足月出生且出生后24 h内完成接种乙肝疫苗的新生儿(未接种第二针乙肝疫苗),其中纳入确诊为HCMV感染的患儿74例计为观察组,另选未被HCMV感染的新生儿74例计为对照组。全程免疫后检测两组血清乙肝表面抗体(抗-HBs)水平、白细胞介素-2(IL-2)、IL-6水平,记录两组对乙肝疫苗初次免疫应答情况,检测两组细胞免疫指标水平(CD3⁺、CD4⁺、CD8⁺、CD4⁺/CD8⁺)。结果观察组血清抗-HBs水平、IL-2水平低于对照组(P<0.05),而血清IL-6水平高于对照组(P<0.05);观察组新生儿对乙肝疫苗初次免疫保护应答率(67.57%)低于对照组(85.14%)(P<0.05);观察组新生儿CD3⁺、CD4⁺、CD4⁺/CD8⁺等低于对照组(P<0.05),CD8⁺水平高于对照组(P<0.05)。结论合并巨细胞病毒感染会使新生儿机体免疫功能处于失衡和抑制状态,导致机体对乙肝疫苗初次免疫时免疫应答率降低,应答强度减弱。

关键词: 巨细胞病毒, 小儿乙肝疫苗, 初次免疫应答, 细胞免疫指标

Abstract: Objective To study the effect of cytomegalovirus infection on the primary immune response to hepatitis B vaccine of infants.Methods A total of 148 full-term newborns (not vaccinated with the second dose of hepatitis B vaccine) were selected from January 2019 to January 2020 in our hospital. Among them, 74 children were diagnosed as human cytomegalovirus (HCMV) infection in our hospital were included in the observation group, and 74 newborns without HCMV infection were selected as the control group.The serum levels of anti-HBs, IL-2 and IL-6 in the two groups were detected after the whole course of immunization. The levels of cellular immune indexes (CD3⁺, CD4⁺, CD8⁺, CD4⁺/CD8⁺) were detected. Results The serum levels of anti-HBs and IL-2 in the observation group were lower than those in the control group (P<0.05), while the serum IL-6 level was higher than that in the control group (P<0.05);The primary immune response rate of observation group (67.57%) was lower than that of control group (85.14%) (P<0.05).The levels of CD3⁺, CD4⁺, CD4⁺/CD8⁺ in the observation group were lower than those in the control group (P<0.05), and the level of CD8⁺ in the observation group was higher than that in the control group (P<0.05).Conclusion Combined with cytomegalovirus infection will make the immune function of newborns in imbalance and inhibition state, which will lead to the decrease of immune response rate and the intensity of immune response to hepatitis B vaccine.

Key words: Cytomegalovirus, Hepatitis B vaccine for children, Primary immune response, Cellular immunity index

叶明, 徐璐, 赵子华, 段双霞. 合并巨细胞病毒感染对小儿乙型肝炎疫苗初次免疫应答的影响[J]. 肝脏, 2021, 26(5): 554-556.

YE Ming, XU Lu, ZHAO Zi-hua, DUAN Shuang-xia. Effect of cytomegalovirus infection on primary immune response to hepatitis B vaccine in infants[J]. Chinese Hepatolgy, 2021, 26(5): 554-556.

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