胰岛素抵抗的NAFLD患者外周血CD4+CD25+调节性T细胞的功能特征

肝脏 ›› 2021, Vol. 26 ›› Issue (6): 667-669.

胰岛素抵抗的NAFLD患者外周血CD4⁺CD25⁺调节性T细胞的功能特征

吕晓玉, 王中京

430014 湖北华中科技大学同济医学院附属武汉中心医院内分泌科

收稿日期:2020-09-22 出版日期:2021-06-30 发布日期:2021-07-19
通讯作者: 王中京,Email:doctorwangzj@163.com
基金资助:
2017年湖北省卫计委科研项目(WJ2017M183)

Functional characteristics of CD4⁺CD25⁺ regulatory T cells in the peripheral blood of NAFLD patients with insulin resistance

LV Xiao-yu, WANG Zhong-jing

Department of Endocrinology, Wuhan Central Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Hubei 430014, China

Received:2020-09-22 Online:2021-06-30 Published:2021-07-19
Contact: WANG Zhong-jing,Email:doctorwangzj@163.com

摘要/Abstract

摘要： 目的研究NAFLD合并IR患者外周血CD4⁺CD25⁺Treg细胞的功能特征。方法将医院2017年1月至2019年12月间收治的30例NAFLD合并IR患者(①组)、30例单纯NAFLD患者(②组)及20例健康志愿者(③组)纳为研究对象,检测并比较三组外周血CD4⁺CD25⁺Treg水平,同时以①组患者HOMA-IR平均值为划分界限,将其分为高IR组及低IR组,比较两组外周血CD4⁺CD25⁺Treg水平。结果 ①组与②组AST、ALT、TC、TG水平均无显著性差异(P>0.05),两组以上指标水平均显著高于③组(P<0.05),①组HOMA-IR水平显著高于②组(P<0.05),两组均显著高于③组(P<0.05);①组外周血CD4⁺CD25⁺Treg水平显著低于②组(P<0.05),且两者CD4⁺CD25⁺Treg水平均显著低于③组(P<0.05);高IR组CD4⁺CD25⁺Treg水平显著低于低IR组(P<0.05)。结论 NAFLD患者外周血CD4⁺CD25⁺Treg数量下降,免疫功能异常,而IR将加重CD4⁺CD25⁺Treg数量的减少,调整患者生活习惯,缓解IR,在NAFLD患者病情中具有积极意义。

关键词: 胰岛素抵抗, 非酒精性脂肪性肝病, 外周血CD4⁺CD25⁺调节性T细胞, 功能特征

Abstract: Objective To investigate the functional characteristics of CD4⁺CD25⁺ regulatory T cells (Treg) in peripheral blood of insulin resistance (IR) patients with nonalcoholic fatty liver disease (NAFLD).Methods 30 cases of NAFLD combined with IR (group ①), 30 cases of NAFLD (group ②) and 20 healthy individuals (group ③) in our hospital from January 2017 to December 2019 were enrolled. Routine laboratory indexes, HOMA-IR levels and peripheral blood CD4⁺CD25⁺Treg levels were detected. According to the average value of HOMA-IR in group ①, they were further divided into high IR group and low IR group, and the levels of CD4⁺CD25⁺ Treg in peripheral blood of the two groups were compared.Results AST, ALT, TC, TG levels of group ① and group ② had no significant difference (P>0.05), while were higher than those of group ③ (P<0.05). Among three groups, HOMA-IR level was the highest in group ①, followed by group ② and group ③(P<0.05), meanwhile, the CD4⁺CD25⁺Treg level was the lowest in group ①, followed by group ② and group ③ (P<0.05). CD4⁺CD25⁺Treg level in high IR group was significantly lower than that in the low IR group (P<0.05).Conclusion The number of CD4⁺CD25⁺Treg in peripheral blood of NAFLD patients is decreased and the immune function is abnormal, while IR will aggravate the reduction of CD4⁺CD25⁺Treg, so it is of positive significance to adjust the living habits of patients to alleviate IR in patients with NAFLD.

Key words: Insulin resistance, Nonalcoholic fatty liver disease, Peripheral blood CD4⁺CD25⁺ regulatory T cells, Functional characteristics

吕晓玉, 王中京. 胰岛素抵抗的NAFLD患者外周血CD4⁺CD25⁺调节性T细胞的功能特征[J]. 肝脏, 2021, 26(6): 667-669.

LV Xiao-yu, WANG Zhong-jing. Functional characteristics of CD4⁺CD25⁺ regulatory T cells in the peripheral blood of NAFLD patients with insulin resistance[J]. Chinese Hepatolgy, 2021, 26(6): 667-669.

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