新生儿黄疸431例病因及临床特点分析

肝脏 ›› 2021, Vol. 26 ›› Issue (6): 677-679.

新生儿黄疸431例病因及临床特点分析

张杰, 李臻, 吴芳, 李雅春

200080 上海上海交通大学附属第一人民医院儿内科

收稿日期:2021-03-06 出版日期:2021-06-30 发布日期:2021-07-19
通讯作者: 李雅春,Email: yachunli@126.com

Analysis of etiology and clinical features of 431 cases of neonatal jaundice

ZHANG Jie, LI Zhen, WU Fang, LI Ya-chun

Shanghai General Hospital, Shanghai 200080, China

Received:2021-03-06 Online:2021-06-30 Published:2021-07-19
Contact: LI Ya-chun,Email: yachunli@126.com

摘要/Abstract

摘要： 目的探讨新生儿黄疸的病因及临床特征,总结经验。方法对我院住院的新生儿黄疸431例进行回顾性分析,比较发病特点,进行统计学处理,分析影响黄疸的病因和高危因素。结果感染因素172例(39.91%)、溶血84例(19.49%)、围生期因素如窒息、头颅血肿等49例(11.37%)、排胎便延迟等肠道原因22例(5.10%)、红细胞增多症4例(0.70%)、不明原因黄疸73例(16.94%),在高危因素中,糖尿病母亲婴儿80例(18.56%)、母亲甲状腺功能减退减45例(10.44%),新生儿低蛋白血症34例(7.89%),新生儿低血糖17例(3.94%)。感染组与非感染组转氨酶异常没有明显差异性。结论感染、溶血及围生期因素是我院新生儿黄疸的主要病因。

关键词: 新生儿黄疸, 病因, 高危因素, 转氨酶

Abstract: Objective To investigate the etiology and clinical characteristics of neonatal jaundice.Methods The clinical data of 431 neonates with jaundice in our hospital were analyzed, and the clinical etiology, high risk factors and the clinical characteristics of the condition of jaundice were analyzed statistically by comparing the correlation of the risk factors.Results There were 172 infectious cases (39.91%) , 84 hemolysis cases (19.49%), 49 cases with perinatal hypoxia and scalp hematoma (11.37%), 22 delayed defecation cases (5.10%), 4 cases with polycythemia (0.70%), and 73 cases with unknown jaundice (16.94%). Among the high risk factors, there were 80 neonatus whose mother with gestational diabetes (18.56%), 45 whose mother with hypothyroidism (10.44%), 34 with neonatal hypoproteinemia (7.89%), and 17 with neonatal hypoglycemia (3.94%). There was no significant deference in transaminase between the infection group and the non-infection group.Conclusion Infection, hemolysis and perinatal factors are the main causes of neonatal jaundice in our hospital.

Key words: Neonate jaundice, Pathogenesis, Transaminase

张杰, 李臻, 吴芳, 李雅春. 新生儿黄疸431例病因及临床特点分析[J]. 肝脏, 2021, 26(6): 677-679.

ZHANG Jie, LI Zhen, WU Fang, LI Ya-chun. Analysis of etiology and clinical features of 431 cases of neonatal jaundice[J]. Chinese Hepatolgy, 2021, 26(6): 677-679.

参考文献

[1] 叶艳艳,邹安庆,林振浪.2006-2015年住院新生儿病因及死亡变化趋势分析. 中国妇幼保健,2016,31:3358-3361.
[2] 黄国日,潘革.新生儿病理性黄疸换血治疗的研究进展. 医学综述,2012,18:380.
[3] Mojtahedi SY, Izadi A, Seirafi G, et al. Risk Factors Associated With Neonatal Jaundice; a Cross-Sectional Study from Iran. Open Access Maced J Med Sci, 2018, 6:1387-1393.
[4] Bowe B, Xie Y,Li T, et al. The 2016 global and national burden of diabetes mellitus attributable to PM2.5 air pollution. Lancet Planet Health,2018,2:e301-e312.
[5] 中华医学会儿科学分会新生儿学组,《中华儿科杂志》编辑委员会.新生儿高胆红素血症诊断和治疗专家共识.中华儿科杂志,2014,52:745-748.
[6] 鲍珊,杨晓燕,唐军,等.新生儿黄疸研究现状的共词分析.中国当代儿科杂志,2014,16:820-823.
[7] Yang L, Wu D, Wang B, et al. The influence of zinc sulfate on neonatal jaundice: a systematic review and meta-analysis. J Maternal Fetal Neonatal Med,2018,31:1311-1317.
[8] Orimadegun AE, Ojebiyi AO. Primary health workers’ knowledge and practices relating to neonatal jaundice in Ibadan, Nigeria. Afr J Prm Health Care Fam Med,2017,9:a1081.
[9] Shabayek S, Spellerberg B. Group B Streptococcal Colonization, Molecular Characteristics, and Epidemiology.Front Microbiol,2018,9:437.
[10] 杜立中.重视新生儿高胆红素血症所致脑损伤的预防和干预.中华儿科杂志,2014,52:721-723.
[11] Ayyappan S, Philip S, Bharathy N, et al. Antioxidant status in neonatal jaundice begore and after phototherapy. J Pharm Bioall Sci, 2015,7:S16-S21.
[12] Wang Z,Kanguru L, Hussein J, et al. Incidence of adverse outcomes associated with gestational diabetes mellitus in low-and middle-income countries, Int J Gynecol Obstet,2013,121:14-19.
[13] Olusanya BO, Kaplan M, Hansen TWR. Neonatal hyperbilirubinaemia: a global perspective. Lancet Child Adolesc Health,2018,2:610-620.
[14] 李海燕,秦道建,张士发. NSE、LDH和CK联合监测对早产儿脑损伤早期诊断的价值. 皖南医学院学报,2018,37:433-436.

[1]	陈琼, 梅红, 高源, 徐平平, 陈晨, 吴玉平. 婴儿胆汁淤积性肝病病因及临床特征分析[J]. 肝脏, 2021, 26(6): 680-683.
[2]	白艳锋, 何玲玲, 魏红山. 食管胃底静脉曲张出血患者低肝脏弹性值原因分析[J]. 肝脏, 2021, 26(5): 490-493.
[3]	俞海英, 钟艳丹, 杨永峰, 彭姗姗, 丁巧云, 郭银燕, 曹兴国. 儿童肝病原因分析[J]. 肝脏, 2021, 26(3): 299-301.
[4]	杜静园, 颜华东. 不同病因肝硬化失代偿患者临床特征及长期预后危险因素的前瞻性队列研究[J]. 肝脏, 2021, 26(2): 140-146.
[5]	郭小青, 李双双, 梁朝朝, 王倩晖. 太原地区肝硬化主要病因调查及其特点分析[J]. 肝脏, 2021, 26(1): 78-80.
[6]	甄丽影. Vanin-1作为对乙酰氨基酚致急性肝损伤早期评价标志物的相关性分析[J]. 肝脏, 2020, 25(7): 679-681.
[7]	刘妲妲, 梁栋, 朱晓红, 张燕, 董晓锋, 王全楚. 白色假丝酵母菌在肝硬化患者中定植水平及其高危因素分析[J]. 肝脏, 2020, 25(7): 714-716.
[8]	梁栋, 陈北方, 彭坤, 张鼎. 新型冠状病毒肺炎患者合并肝损伤的回顾性分析[J]. 肝脏, 2020, 25(5): 469-471.
[9]	卢君瑶, 王登宇, 尹东林, 白玉盘, 许洁. HBV相关肝细胞癌的临床特征及危险因素分析[J]. 肝脏, 2020, 25(3): 285-287.
[10]	梅栖榕, 杨丽, 沈毅. 慢性乙型肝炎患者长期服用阿德福韦酯与肾性低磷血症的相关性[J]. 肝脏, 2020, 25(3): 311-313.
[11]	刘永红, 王鑫, 马顺茂. 肝穿刺活检判断非病毒性肝病患者病因的临床研究[J]. 肝脏, 2020, 25(3): 316-318.
[12]	陆伟, 刘丹萍, 张占卿, 王雁冰, 丁荣蓉, 周新兰, 黄丹, 李秀芬, 杨可芷. APRI、GPR和FIB-4预测抗病毒诱导的乙型肝炎肝硬化肝脏病理学回归的性能评价[J]. 肝脏, 2019, 24(8): 875-882.
[13]	龙柳艳, 韦晓谋. 非酒精性脂肪性肝病患者血清Betatrophin水平评估病情严重程度的应用价值[J]. 肝脏, 2019, 24(8): 933-935.
[14]	周保仓. 转氨酶正常或轻度增高的慢性乙型肝炎患者肝穿刺活检病理特征[J]. 肝脏, 2019, 24(3): 253-255.
[15]	李文华, 刘晓红, 朱国艳, 戴成艳. N-乙酰半胱氨酸对TACE肝癌患者凝血酶原、胆红素和谷丙转氨酶的影响[J]. 肝脏, 2019, 24(3): 295-296.