关键词: 慢性肝衰竭, 药物性肝损伤, 临床分析

Abstract: Objective To analysis the clinical and laboratory findings of patients with drug-induced chronic liver failure. Methods The laboratory test results of patients with drug-induced chronic liver failure who were hospitalized in Beijing You'an Hospital Affiliated to Capital Medical University from January 2018 to June 2021 were retrospectively analyzed. Results A total of 12 patients were included, with a male to female ratio of 1:11. All patients (100%) had jaundice, 10 patients (83.33%) had splenomegaly, 9 patients (75%) had ascites, and 4 patients had grade 3 ascites. There were 3 cases of grade 2 ascites and 1 case of hepatic encephalopathy (8.33%). 75% of the patients were accompanied by moderate to severe anemia, and the platelet counts of 12 patients were all below 100×10⁹/L. The prothrombin times of all patients were prolonged by more than 3s, with INR higher than the upper limit of normal reference value. The bilirubin levels were elevated, especially DBil. The patient's ALT, AST, DBil, GGT ALP were (38.92±39.86) U/L, (78.08±73.58) U/L, (101.61±78.73) μmol/L, (37.42±34.28 ) U/L and (110.83±40.42) U/L, respectively. Conclusion The laboratory indicators and clinical characteristics of patients with drug-induced chronic liver failure have their own specialties The more serious the disease presents, and the worse of the prognosis.

Key words: Chronic liver failure, Drug-induced liver injury, Clinical analysis