免疫检查点抑制剂相关乙型肝炎病毒再激活研究进展

摘要/Abstract

摘要： 慢性乙型肝炎、恶性肿瘤是影响全球健康的两大公共问题。随着新兴抗肿瘤药物免疫检查点抑制剂(ICIs)适应证的扩大,陆续出现了免疫检查点抑制剂(immune checkpoint inhibitors, ICIs)导致 HBV再活化(HBVr)的系列报道。HBVr可表现为严重肝损伤甚至肝衰竭,影响患者生存及预后。故笔者汇总国内外相关研究进展,总结免疫检查点在乙肝病毒感染过程中的作用机制,汇总国内外关于乙肝患者使用免疫检查点抑制剂的管理建议,为乙肝患者制定使用免疫检查点抑制剂(ICIs)治疗策略提供参考。

关键词: 免疫检查点抑制剂 , 恶性肿瘤, 乙型肝炎病毒, 再激活

雷定佳, 秦波. 免疫检查点抑制剂相关乙型肝炎病毒再激活研究进展[J]. 肝脏, 2022, 27(10): 1135-1138.

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