成纤维细胞生长因子21治疗非酒精性脂肪性肝病的临床研究进展及相关机制

摘要/Abstract

摘要： 成纤维细胞生长因子21(FGF21)是成纤维细胞生长因子家族(FGF)中的一员,在维持机体能量代谢平衡等过程中发挥重要作用。近期两项FGF21类似物治疗非酒精性脂肪性肝病(NAFLD)的临床试验均达到各自的主要疗效评价终点。FGF21可以调控NAFLD相关的发病因素如糖脂代谢异常,还能改善炎症、抗应激损伤、抗纤维化和抑制NASH相关的HCC的发生。本文通过对FGF21类似物治疗NAFLD临床研究进展及相关机制研究进展进行综述,以全面介绍FGF21在NAFLD研究领域的进展。

关键词: 成纤维细胞生长因子21, 非酒精性脂肪性肝病, 临床研究, 机制

安梓铭, 孙沁梅, 辛鑫, 胡义扬, 冯琴. 成纤维细胞生长因子21治疗非酒精性脂肪性肝病的临床研究进展及相关机制[J]. 肝脏, 2022, 27(10): 1139-1142.

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