肝巨噬细胞和血小板在肝纤维化中的研究进展

摘要/Abstract

摘要： 肝纤维化是肝脏慢性损伤时出现过度修复反应,导致正常组织被取代而形成纤维疤痕的过程。肝巨噬细胞参与肝纤维化进展或消退的所有阶段,其作为肝纤维化的核心参与者,对肝纤维化具有双重调控作用。目前研究发现血小板除了血栓形成与止血功能,还可以通过分泌多种活性物质直接影响肝纤维化,或与肝巨噬细胞相互作用共同调控肝纤维化。研究肝巨噬细胞和血小板及其两者的相互作用在肝纤维化中的影响,可以为抗肝纤维化提供新靶点与治疗思路。

曾秋月, 奉镭, 王华敏. 肝巨噬细胞和血小板在肝纤维化中的研究进展[J]. 肝脏, 2024, 29(7): 773-776.

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