Epidemiology analysis of relationship between Fibrotouch tests and demographic features in chronic hepatopathy patients

Abstract

Abstract: Objective To analyze the relationship between Fibrotouch tests and demographic features in chronic liver diseases.Methods Demographic features of chronic hepatopathy patients, including gender, age and body mass index (BMI), and parameters of Fibrotouch tests were collected and statistically analyzed.Results Compared to the male, female patients had significantly lower liver stiffness and fat attenuation (all P<0.001). Age, BMI and fat attenuation were positively associated with liver stiffness, with Spearman’s correlation coefficient as 0.301, 0.187 and 0.107, respectively (all P<0.001). Additionally, age and BMI were statistically positively related with fat attenuation, with Spearman’s correlation coefficient as 0.121 and 0.695, respectively (all P<0.001).Conclusion Age, gender and BMI were associated with Fibrotouch results, which might help Fibrotouch in diagnosis of chronic liver diseases.

Key words: Chronic liver diseases, Fibrotouch, Body mass index, Age, Gender, Epidemiology analysis

YE Pei-yan, LU Yun-fei, CHEN Xiao-rong, YANG Zong-guo. Epidemiology analysis of relationship between Fibrotouch tests and demographic features in chronic hepatopathy patients[J]. Chinese Hepatolgy, 2016, 21(7): 539-541.

References

[1] Shaheen AA, Wan AF, Myers RP. FibroTest and FibroScan for the prediction of hepatitis C-related fibrosis: a systematic review of diagnostic test accuracy. Am J Gastroenterol,2007, 102:2589-2600.
[2] Scott DR, Levy MT. Liver transient elastography (Fibroscan):a place in the management algorithms of chronic viral hepatitis. Antivir Ther,2010, 15:1-11.
[3] 中华医学会肝病学分会,中华医学会感染病学分会. 慢性乙型肝炎防治指南(2010年版). 肝脏,2011, 16:2-16.
[4] 陈容容,林志辉. 瞬时弹性成像技术(FibroTouch)定量评价非酒精性脂肪肝的临床研究. 福州:福建医科大学,2014:9-10.
[5] National Clinical Guideline Centre (UK). Obesity: Identification, Assessment and Management of Overweight and Obesity in Children, Young People and Adults: Partial Update of CG43. London: National Institute for Health and Care Excellence (UK),2014,National Institute for Health and Clinical Excellence: Guidance .
[6] 肝脏硬度评估小组. 瞬时弹性成像技术诊断肝纤维化专家意见. 中华肝脏病杂志,2013, 21:420-424.
[7] 王荣琦,任伟光,赵素贤,等. 瞬时弹性成像技术与多参数模型评估慢性肝病肝纤维化程度的临床研究. 中华肝脏病杂志,2015, 23:265-269.
[8] Das K, Sarkar R, Ahmed SM, et al. "Normal" liver stiffness measure (LSM) values are higher in both lean and obese individuals: a population-based study from a developing country. Hepatology,2012,55:584-593.
[9] Sasso M, Tengher-Barna I, Ziol M, et al. Novel controlled attenuation parameter for noninvasive assessment of steatosis using Fibroscan(R): validation in chronic hepatitis C. J Viral Hepat,2012,19:244-253.
[10] 陈学兵,朱霞,陈立宇,等.丙氨酸转氨酶对FibroScan诊断慢性乙型肝炎肝纤维化分期的影响. 中华肝脏病杂志,2011, 19:286-290.
[11] 朱梦飞,刘静,王洁,等. FibroTouch 及 FibroScan R实施受控衰减参数评价肝细胞脂肪变与肝脏病理比较分析. 中国实用内科杂志,2014, 34:589-593.
[12] Sasso M, Beaugrand M, de Ledinghen V, et al. Controlled attenuation parameter (CAP): a novel VCTE guided ultrasonic attenuation measurement for the evaluation of hepatic steatosis: preliminary study and validation in a cohort of patients with chronic liver disease from various causes. Ultrasound Med Biol,2010,36:1825-1835.
[13] 沈峰,徐正婕,潘勤,等.FibroScan R实施受控衰减参数评价脂肪肝的影响因素及重复性分析. 实用肝脏病杂志,2013,16:59-62.

[1]	LI Jing, ZHANG Ming-zhi, LIU Jia-kai, SHI Bo, LUO Li. Analysis of the difference between solitary necrotic nodule of the liver and single metastatic liver cancer in contrast-enhanced ultrasound [J]. Chinese Hepatolgy, 2020, 25(5): 483-485.
[2]	HU Hua-hua, LIU Jun, GUAN Li-yu, XU Jie-hong, YI Hong, LI Zhong-zhuan, QIN Shu-fen, DENG Xiang-yu. Hemodynamic analysis of liver cirrhosis complicated with esophageal and gastric varices rupture [J]. Chinese Hepatolgy, 2020, 25(4): 369-371.
[3]	ZHUANG Yan, LU Jie, XIE Qing, LIN Lan-yi.. Study on the current status of Direct-acting antiviral Treatment in Chinese patients with HCV-related liver cirrhosis [J]. Chinese Hepatolgy, 2020, 25(3): 249-253.
[4]	CHENG Jing, XU Lu, PENG Su-qiong.. Predictive value of hepatic hemodynamics ultrasonic parameters combined with peripheral blood vWF-Ag in esophageal varices hemorrhage in patients with liver cirrhosis [J]. Chinese Hepatolgy, 2020, 25(3): 260-263.
[5]	WANG Jia-huan, LI Zhen. Clinical efficacy comparison of percutaneous radiofrequency ablation and laparoscopic liver resection for the treatment of stage Ia primary liver cancer [J]. Chinese Hepatolgy, 2020, 25(2): 146-148.
[6]	TIAN Chun-li, LIANG Ke-feng, ZHAO Yu. Analysis of etiology and clinical characteristics of drug-induced liver injury in children [J]. Chinese Hepatolgy, 2020, 25(1): 31-33.
[7]	MENG Qing-yang, XU Chun-lin, KANG Peng. Ox-LDL-induced ETs production of macrophages in patients with cirrhosis [J]. Chinese Hepatolgy, 2019, 24(9): 1007-1010.
[8]	WU Jiang-hua, MA Jun-Ji, GUO Yu, GUO Ping. SB-525334 downregulates the expression of miR-19b and miR-29b in hepatic stellate cells [J]. Chinese Hepatolgy, 2019, 24(9): 1011-1014.
[9]	TANG Ying-yue, LI Jing, LEI Xiao-hong, LI Chun-min, ZENG Min-de, MAO Yi-min. Preliminary analysis of changes of hepatic macrophages and lymphocyte subsets in CCl₄-induced hepatic fibrosis in mice [J]. Chinese Hepatolgy, 2019, 24(4): 377-381.
[10]	LU Jie, CHEN Li-chang, ZHOU Hui-juan, XIE Qing, LIN Lan-yi. Current status of antiviral therapy for chronic HCV infection in China [J]. Chinese Hepatolgy, 2019, 24(11): 1230-1233.
[11]	GU Jing, CHEN Zu-tao, SUN Wei, GAN Jian-he. Changes of serum alkaline phosphatase in patients with HBV-related acute-on-chronic liver failure and its significance [J]. Chinese Hepatolgy, 2019, 24(11): 1234-1236.
[12]	WANG Dan, MU Jin-song, HU Zhi-jun, YAN Bing-bing, KUANG Zhi-dan. Prognostic risk factors in patients with cirrhosis and cerebral hemorrhage [J]. Chinese Hepatolgy, 2019, 24(10): 1116-1118.
[13]	WANG Pu, DONG Yi, XU Zhi-qiang, CHEN Da-wei, WANG Fu-chuan, GAN Yu, WANG Li-min, YAN Jian-guo, CAO Li-li, LI Ai-qin, ZHU Shi-shu,ZHANG Min. Clinical and pathological features and gene mutation analysis in 12 Chinese patients with glycogen storage disease type Ⅸ [J]. Chinese Hepatolgy, 2018, 23(9): 764-768.
[14]	YIN Yan-xia, MENG Zi-qiang, LI Xiao-guang, YU Jian-wu, LI Shu-chen, XU Chun-hai. Clinical effect of direct-acting antiviral agents for chronic hepatitis C [J]. Chinese Hepatolgy, 2018, 23(9): 772-774.
[15]	YUAN Xiao-ling, Bai Yu-pan, YIN Dong-lin, HONG Shen-zhen, Bao Yu-jie, ZHOU Yuan-yuan, YAN Lei, KANG Yao-yue, FAN Shan, CAO Jun-ying, XU Jie. Influence of SII and NLR on the survival time in patients with malignant obstructive jaundice treated with PTCD implantation of biliary mental stents [J]. Chinese Hepatolgy, 2018, 23(6): 492-495.