Abstract: Objective To study the relationship between the level of interleukin-17 (IL-17) gene polymorphism and the outcome of patients with chronic hepatitis B virus (HBV) infection.Methods Fifty-four cases of chronic hepatitis B from June 2017 to June 2018 were included as the observation group and 54 cases of asymptomatic chronic HBV infection were as the control group.The level of serum IL-17 was compared between the two groups.The HBV DNA content was quantitatively detected by PCR and fluorescent probe,and the distribution of IL-17 rs763780 gene polymorphism was detected by PCR amplification instrument.The incidence of progression to cirrhosis in different genotypes within one year was compared.Results The serum IL-17 of the observation group was significantly higher than that of the control group,and the incidence of HBV DNA content >1×10³ was higher than that of the control group (P<0.05).There were significant difference in the frequency distribution of IL-17 rs763780 genotype and allele between the two groups (P<0.05).The incidence of cirrhosis in TT genotype of IL-17 rs763780 were significantly higher than those in CC genotype and CT genotype (P<0.05).Conclusion The polymorphism of IL-17 gene is closely related to HBV infection.The patients with TT genotype and T allele of IL-17 rs763780 locus are more likely to have chronic HBV infection,and the incidence of cirrhosis is higher.

Key words: IL-17 gene polymorphism, Hepatitis B virus, Prognosis, Correlation