Abstract: Objective To analyze the effects of different concentrations of iodine contrast agent on the blood perfusion parameters of primary hepatocellular carcinoma (HCC) measured by 64-row multidetector computed tomography (MDCT),and provide further refined imaging diagnosis of primary liver cancer and references for the safety of iodine contrast agent.Methods Eighty-four patients with HCC were selected by case sampling method.Informed consent was obtained from all patients and their families.Equal numbers of patients were randomly assigned to different concentrations of iodine contrast agent groups,with 300 mg I/mL (1.90 mL/kg) in group A and 380 mg/mL (1.50 mL/kg) in group B.Multi-slice spiral CT (MSCT) was performed in both groups of patients.The association between the CT imaging results as measured by different concentrations of iodine contrast agent and the blood flow dynamic parameters of HCC were analyzed.Results The detection sensitivity of The CT values of hepatic parenchymal portal phase,aortic arterial phase,and portal vein phase and the arterial phase of group A patients were significantly higher,whereas the liver perfusion parameters including hepatic blood flow (BF),blood volume (BV),and hepatic artery perfusion (HAP) were significantly lower than those in group B (both P<0.05).Conclusion when detecting primary liver cancer with 64-row MDCT,using a higher concentration of iodine contrast agent [380 mg I/mL (1.50 mL/kg)] has better sensitivity,corresponding to relative lower values of hepatic artery and portal vein pressure in the blood flow perfusion parameters.The causal relationship warrants further validation.

Key words: 64-row multidetector computed tomography, Concentration of iodine contrast agent, Primary liver cancer, Blood perfusion parameters, Clinical significance