Treatment effect of sofosbuvir combined with velpatasvir on patients with hepatitis C viral infection

Abstract

Abstract: Objective To determine the efficacy and safety of NS5B inhibitor sofosbuvir (SOF) combined with NS5A inhibitor velpatasvir (VEL) in the treatment of patients with chronic hepatitis C virus infection (CHC).Methods A total of 72 CHC patients received SOF/VEL 400/100 mg daily for 12 weeks, The patients were then tested for serum HCV RNA and liver function, including parameters of Alanine aminotransferase (ALT), Aspartate aminotransaminase (AST), total bilirubin (TBil). The safety of the medication was also evaluated.Results Serum AST, ALT and TBIL levels of the hepatitis C patients were significantly decreased after 4 and 12 weeks of SOF/VEL treatment (P<0.05). APRI index also significantly decreased at these time points (P<0.05). HCV RNA was below the detection limit in 42 patients (57%) after 2 weeks of antiviral treatment, and in 64 (89%), 69 (96%) and 70 patients (97%) after 4, 8 and 12 weeks of continued treatments, respectively. High sustained virologic response (SVR) rates were achieved in 18 patients with genotype 2a (100%), 43 patients with genotype 1b (97%), and 6 patients with genotype 3 (75%) at the end of 12 weeks' treatment (SVR12). respectively. Adverse reactions were reported in 46 (64%) patients during the treatment, which were most commonly headache, fatigue, nausea, cough and other mild symptoms.Conclusion SOF/VEL treatment is effective in patients with genotypes 1b, 2a and 3 HCV infection. The medication also has significant early efficacy, low incidence and mild adverse reactions, and high clinical safety.

Key words: Sofosbuvir, Velpatasvir, Hepatitis C, NS5A inhibitor, NS5B inhibitor

LIU Yang, XU Li, FENG You-cheng, JIANG Sheng-chang. Treatment effect of sofosbuvir combined with velpatasvir on patients with hepatitis C viral infection[J]. Chinese Hepatolgy, 2021, 26(1): 33-36.

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