Abstract: Objective To investigate the clinical effect of intraperitoneal catheterization and lavage combined with intraperitoneal injection of antibiotics in the treatment of spontaneous peritonitis (SBP) of liver cirrhosis.Methods Seventy-three patients with cirrhosis and SBP from June 2016 to June 2019 in our hospital were randomly divided into a treatment group and a control group. The control group was treated with intravenous drip infusion of antibiotics, while the treatment group was treated with intraperitoneal catheterization and lavage combined with intraperitoneal injection of antibiotics on the basis of the control group. The course of treatment was 14 days. The symptoms and signs (fever, abdominal pain, abdominal distention, abdominal tenderness and rebound pain, etc) were observed before and after treatment. The liver function indexes (alanine aminotransferase, aspartate aminotransferase, total bilirubin) and inflammation indexes (white blood cell count, procalcitonin and C-reactive protein) were recorded before and after treatment.Results In the treatment group, the remission time of clinical symptoms and signs were shorter than the control group (P<0.05). The liver function and inflammatory indexes improved more than the control group (P<0.05). The efficacy rate and total effective rate of the treatment group were higher than those of the control group (P<0.05).Conclusion Intraperitoneal catheterization and lavage combined with intraperitoneal injection of antibiotics can significantly alleviate the clinical symptoms and signs of SBP, and improve the liver function and inflammatory indicators, with high treatment efficacy.

Key words: Peritoneal lavage, Intraperitoneal injection, Cirrhosis, Spontaneous peritonitis