The value of transient elastography in evaluating the severity of liver fibrosis in non-alcoholic steatohepatitis

Abstract

Abstract: Objective To explore the value of transient elastography in evaluating the severity of liver fibrosis in non-alcoholic steatohepatitis.Methods The research subjects selected 236 patients with non-alcoholic steatohepatitis admitted to our hospital from September 2018 to September 2019. According to the degree of liver puncture fibrosis, all patients were divided into 5 groups, which were group A (50 Cases), group B (47 cases), group C (52 cases), group D (44 cases), group E (43 cases). Liver stiffness (LSM) was detected using instantaneous elastic ultrasound imaging within 1 week of liver puncture. The LSM of 5 groups of patients was compared, and the relationship between LSM and the severity of liver fibrosis was analyzed. Draw the ROC of all patients. When calculating and evaluating the severity of non-alcoholic steatohepatitis liver fibrosis, the area under the curve (AUC), specificity and sensitivity were detected.Results Group A LSM was (5.14±1.51) kPa, Group B LSM was (7.42±1.48) kPa, Group C LSM was (9.34±1.63) kPa, Group D LSM was (11.82±1.66) kPa, Group E LSM was (13.61±1.65) kPa. The five groups of LSMs were ranked from low to high, followed by Group A, Group B, Group C, Group D, and Group E, and compared among the five groups, the difference between the groups was significant (P<0.05). Logistic linear regression was used to analyze the correlation between LSM and liver fibrosis stage, and it was found that LSM was positively correlated with liver fibrosis stage (r=0.712), and the difference was statistically significant (P=0.001). The AUC of group B, group C, group D and group E were 0.761, 0.871, 0.910, 0.932, the diagnostic cut-off values were 6.33 kPa, 7.78 kPa, 9.14 kPa, 10.93 kPa, and the specificity was 82.4%, 79.3%, 95.1%, 98.5%, and sensitivities of 73.1%, 76.3%, 88.2%, and 89.5%, respectively.Conclusion Transient elastography is of high application value when it is used to evaluate the degree of non-alcoholic steatohepatitis liver fibrosis, especially when it is applied to S3 and S4 liver fibrosis, its specificity and sensitivity are high.

Key words: Transient elastography, Nonalcoholic steatohepatitis, Liver fibrosis

GUO Yuan, ZHONG Yu-dong. The value of transient elastography in evaluating the severity of liver fibrosis in non-alcoholic steatohepatitis[J]. Chinese Hepatolgy, 2021, 26(1): 64-66.

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