Abstract: Objective To investigate the circulating levels of omentin1, visceral adipose tissue-derived serine protease inhibitor(vaspin) in NAFLD patients and to clarify their relationship with biochemical parameters, interleukin-6(IL-6), and C reactive protein(CRP).Methods One hundred and eight patients with NAFLD (NAFLD group), confirmed fatty liver by B-ultrasound, 129 healthy controls as control group. Height, weight, waist circumference, body mass index (BMI), blood biochemistry, serum CRP, IL-6, omentin-1, vaspin and apelin levels were recorded.Results Compared with the control group, the levels of serum vaspin in the NAFLD group were increased, the levels of omentin-1 were decreased, and the levels of IL-6 and CRP were increased. The difference was statistically significant (P<0.05). The vaspin levels were directly proportional to WC, LDL-C, CRP, and IL-6 (r values were 0.231 to 0.341, both P<0.05); negatively correlated with HDL-C and omentin-1 (r values were -0.221, -0.246, respectively, both P< 0.05). Serum omentin-1 levels were negatively correlated with WC, CRP and IL-6 (r value was -0.238 to -0.319, both P<0.05), and positively correlated with HDL-C (r=0.326, P<0.05). Logistic regression analysis showed that omentin-1, vaspin, waist circumference, CRP, IL-6 were independent factors related to NAFLD in patients [β values were 1.471-2.012, OR (1.021-3.012), 95% CI (1.431-4.779), both P< 0.05].Conclusion In patients with NAFLD, levels of omentin-1, vaspin, IL-6, and CRP were different from those in the healthy group. Vaspin may be predictors of NAFLD, and omentin-1 may be a protective factor against the development of NAFLD. Its mechanism may be related to inflammatory factors. The specific mechanism needs further study.

Key words: Nonalcoholic fatty liver disease, Omentin-1, Vaspin