Abstract: Objective To study on the clinical characteristics and prognosis factors of hepatitis B-related acute liver failure.Methods A total of 14 cases with hepatitis B-related Acute Liver Failure (ALF) were collected from January 2010 to January 2020. They were divided into the survival group and the dead group based on their outcomes. Their clinical features and laboratory examinations were collected and analyzed by SPSS statistic software. Results Within the 14 cases of Hepatitis B-related ALF, 7 (50%) patients were cure and 7 (50%) patients died. The levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total Bilirubin (TBIL) and HBV DNA did not differ obviously between these two groups at admission. However, there were significant difference in blood ammonia (NH3) level, grades of hepatic encephalopathy, and prothrombin time activity (PTA) (P<0.05).Conclusion Acute hepatitis B-related acute liver failure is one of the rare critical clinical conditions, which have the features of acute onset, quick progression and high mortality. The degree of hepatic encephalopathy, high serum ammonia level and decreased PTA at admission may indicate a poor prognosis.

Key words: Acute hepatitis B, Acute liver failure, Prognosis