Chinese Hepatolgy ›› 2021, Vol. 26 ›› Issue (2): 125-127.

• Liver Failure • Previous Articles     Next Articles

Beclin1 and miRNA-130a expression correlated with the prognosis of patients with HBV-related acute-on-chronic liver failure

CHEN Chong-gao1, FU Hou-xuan1, WANG Xiao-zhi2, XIE Hui-zhong3   

  1. 1. Department of critical medicine, Chengmai County People's Hospital, Chengmai, Hainan, 571900;
    2. Department of critical medicine, the Second Affiliated Hospital of Hainan Medical College, Haikou, Hainan, 570100;
    3. Department of Gastroenterology, the Second Affiliated Hospital of Hainan Medical College, Haikou, Hainan, 570100
  • Received:2020-05-01 Online:2021-02-28 Published:2021-03-28

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Abstract: Objective To explore the correlation between the autophagy-related protein (Beclin1) and miRNA-130a and the prognosis of patients with hepatitis B virus (HBV)-related acute-on-chronic liver failure (HBV-ACLF).Methods The clinical data of 132 HBV-ACLF patients were retrospectively analyzed. They were divided into a survival group (65 cases) and a death group (67 cases) according to the survival status after admission for 6 months. 62 healthy people were selected as the normal control group during the same period of time. Serum Beclin1 and miRNA-130a levels were detected in all people in three groups. Receiver operating characteristics (ROC) curves were used to analyze the diagnostic value of these two parameters for HBV-ACLF patients. Results The serum level of Beclin1 in the death group was significantly higher than that in the survival group and the normal control group (P<0.05), and the serum level of Beclin1 in the survival group was significantly higher than the normal control group (P<0.05). Similarly, the expression of serum miRNA-130a in the death group and survival group was significantly higher than that in the normal control group (P<0.05). However, the expression of serum miRNA-130a in the death group was significantly lower than that in the survival group (P<0.05). According to ROC curve analysis, it was found that Beclin1 and mirna-130a had certain diagnostic value for the prognosis of HBV-ACLF patients. The area under the curve (AUC) was 0.811 and 0.836, the sensitivity was 0.791 and 0.851, and the specificity was 0.800 and 0.815, respectively.Conclusion Serum Beclin1 and miRNA-130a are closely associated with the prognosis of HBV-ACLF patients, which should be further investigated in clinical practice.

Key words: Autophagy-related protein, miRNA-130a, Hepatitis B virus-associated acute-on-chronic liver failure, Prognosis