The research of the expression of HCV RNA and core protein in the tissues of HCV-related hepatocellular carcinoma with bile duct tumor thrombus

Abstract

Abstract: Objective To study the clinical significance of the expression of hepatitis C virus (HCV) RNA and core protein in the tissues of hepatitis C virus (HCV)-related hepatocellular carcinoma.Methods Fifty-four patients of HCV-related hepatocellular carcinoma were included as the research subjects,the positive rates of HCV RNA and HCV core protein in the patients of HCV-related hepatocellular carcinoma of cancer tissue and paracancerous tissue were detected.The positive rates of HCV RNA and HCV core protein between cancer and adjacent tissues were compared,the positive rates of HCV RNA and HCV core protein in cancer tissues of patients with different stages and differentiation were compared. Results There was significant difference in the positive rate of HCV RNA between cancer tissue and adjacent tissue (P<0.05).There was significant difference in the positive rate of HCV core protein between cancer tissue and adjacent tissue (P<0.05).The distribution of HCV RNA positive rate and HCV core protein positive rate in the patients of HCV related hepatocellular carcinoma was consistent (Kappa value=0.951,P=0.000).The positive rate of HCV RNA was significantly different in different pathological stages (P<0.05).The positive rate of HCV RNA in different differentiated cancer tissues was significantly different (P<0.05).The positive rate of HCV core protein was significantly different in different stages (P<0.05).The positive rate of HCV core protein in different differentiated cancer tissues was significantly different (P<0.05).Conclusion The positive rate of HCV RNA and core protein are related to the occurrence of HCV-related hepatocellular carcinoma.It is helpful to the diagnosis and treatment of HCV-related hepatocellular carcinoma by monitoring the content of HCV RNA and core protein.

Key words: Hepatitis C virus-related hepatocellular carcinoma, Cancer tissue, HCV RNA, Core protein

ZHANG Bo, ZHANG Yu-fen. The research of the expression of HCV RNA and core protein in the tissues of HCV-related hepatocellular carcinoma with bile duct tumor thrombus[J]. Chinese Hepatolgy, 2021, 26(2): 179-181.

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