Abstract: Objective To analyze the risk factors of post-operative complications in patients with liver cirrhosis after endoscopic retrograde cholangiopancreatography (ERCP), and to provide guidance for the prevention of these complications. Methods The clinical data of 96 cases of liver cirrhotic patients that had received ERCP were retrospectively analyzed. The patients were divided into with complication group and without complication group according to whether they presented postoperative complications. Single and multi-factor analysis were performed in the cirrhotic patients to identify the risk factors for post-operative complications after ERCP treatment. Results Within the 96 cirrhotic patients that had received ERCP, 18 patients(18.75%)presented postoperative complications. The preliminary single-factor analysis showed that esophageal varices, ascites, history of sphincter of Oddi dysfunction (SOD), repeated intubation, cholangiopancreatography, and pre-cut were the risk factors of post-operative complications after ERCP (P<0.05). The result of Logistic regression analysis showed that esophageal varices, ascites, history of SOD, repeated intubation, cholangiopancreatography, and pre-cut were the risk factors of developing complications after ERCP in the patients with liver cirrhosis (OR>1, P<0.05). Conclusion Esophageal varices, ascites, history of SOD, repeated intubation, cholangiopancreatography, and pre-cut increase the risk of complications of ERCP in liver cirrhotic patients. Patients with these risk factors should therefore obtain active intervention to improve the prognosis after ERCP.

Key words: Liver cirrhosis, Endoscopic retrograde cholangiopancreatography, Complications, Risk factors