Abstract: Objective To study the incidence and etiology of liver disease in children under 14 years old. Methods From January 2016 to December 2019, 676 outpatients and inpatients with liver disease in our hospital were collected and divided into six groups according to their ages. The incidence of liver disease in different age groups was analyzed, and the causes of 676 patients were analyzed. Results Among 676 cases, 554 cases were male (81.95%), 122 were female (18.05%), and the incidence rate was high in male. 199 cases were diagnosed as liver diseases in 3~6 years old group (27.96%), and the U value was 3.18 (P<0.01). There were 407 cases of chronic hepatitis B (60.21%), 74 cases of non-alcoholic fatty liver (10.95%), 36 cases of abnormal liver function (5.32%). There were 19 cases with drug-induced hepatitis (2.81%), 18 with CMV hepatitis (2.66%), 11 with chronic hepatitis C (1.63%), 8 with hepatitis A (1.18%), 6 with EBV hepatitis (0.88%), 3 with acute hepatitis B (0.44%) and 1 with hepatoblastoma (0.15%). After routine serological examination and imaging examination, 93 cases (13.76%) were still unclear about the cause of liver disease. After liver biopsy or / and related gene detection in 66 cases, there were 21 cases of Gilbert's syndrome (22.58%), 11 cases of hepatolenticular degeneration (11.83%), 9 cases of progressive muscular dystrophy (9.68%), 6 cases of autoimmune hepatitis (6.45%), 4 cases of glycogen accumulation (4.30%) and 3 cases of Dubin Johnson (6.45%) There were 2 cases of glucose-6-phosphate dehydrogenase deficiency, 2 cases of progressive familial cholestasis and 2 cases of Alagille syndrome, accounting for 2.15% respectively; there were 1 case of overlap syndrome, 1 case of sclerosing cholangitis, 1 case of rotor syndrome and 1 case of hereditary spherocytosis, accounting for 1.075% respectively. There were still 2 cases of unknown etiology. Conclusion There were many causes of liver disease in children under 14 years old, mainly chronic hepatitis B; and children with unexplained abnormal liver function; genetic metabolic abnormalities leading to liver disease was the main reason.

Key words: Under 14 years old,liver disease,Etiology