Chinese Hepatolgy ›› 2021, Vol. 26 ›› Issue (3): 309-311.

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Effect of vitamin D supplementation on biochemical indexes and prognosis of infantile hepatitis syndrome

LIU Zi-hui, SHI Jing, LI Jun-jun, OUYANG Zhen-rong, LEI Ye-fei   

  1. PICU, Chenzhou first people's Hospital, Hunan 423000, China
  • Received:2020-05-18 Published:2021-04-21
  • Contact: SHI Jing

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Abstract: Objective To explore the effect of vitamin D supplementation on biochemical indexes and prognosis of infant hepatitis syndrome (IHS). Methods 112 children with IHS admitted to our hospital from November 2016 to November 2019 were divided into two groups according to the random number table method, 56 cases in each group, of which the control group was treated with routine treatment, and the observation group was supplemented with vitamin D on the basis of routine treatment, all of which lasted for 10 days. We observed clinical curative effect of two groups, and compared serum direct bilirubin (DBil), total bilirubin (TBil), glutamyl transpeptidase (γ-GT), alanine aminotransferase (ALT) level of two groups before and after treatment, serum 25-hydroxyl vitamin D3 [25 (OH) D3], monocyte nuclear factor kappa B (NF-κB) predominate, tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6) levels of two groups before and after treatment were analyzed, and we observed adverse reactions of two groups of children. Results The total effective rate of the observation group was 92.86%, which was significantly higher than 75.00% of the control group (P<0.05). The serum levels of DBil, TBil, γ-GT and ALT in the observation group were significantly lower than those before and after treatment in the control group (P<0.05). The serum 25 (OH) D3 in the observation group was significantly higher than that before and after treatment in the control group (P<0.05), and NF-κB, TNF-α, IL-6 were significantly lower than that before and after treatment in the control group (P<0.05). During the treatment period, there were no dysphoria, anorexia, nausea, fever, arrhythmia and other adverse reactions in all children in the two groups. Conclusion Vitamin D supplementation for children with IHS had definite effect, could effectively alleviate inflammatory reaction and liver injury, and with good safety, which should be paid enough attention in clinical practice.

Key words: Vitamin D, Infantile hepatitis syndrome, Liver function, Inflammatory factors