[1] Singer M, Deutschman CS, Seymour CW, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA, 2016, 315: 801-810.
[2] Yan J, Li S, Li S. The role of the liver in sepsis. Int Rev Immunol, 2014, 33: 498-510.
[3] Kramer L, Jordan B, Druml W, et al. Incidence and prognosis of early hepatic dysfunction in critically ill patients--a prospective multicenter study. Crit Care Med, 2007, 35: 1099-1104.
[4] Man SM, Karki R, Kanneganti TD. Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases. Immunol Rev, 2017, 277: 61-75.
[5] Cervantes J, Nagata T, Uchijima M, et al. Intracytosolic Listeria monocytogenes induces cell death through caspase-1 activation in murine macrophages. Cell Microbiol, 2008, 10: 41-52.
[6] Jorgensen I, Miao EA. Pyroptotic cell death defends against intracellular pathogens. Immunol Rev, 2015, 265: 130-142.
[7] Broz P, Dixit V M. Inflammasomes: mechanism of assembly, regulation and signalling. Nat Rev Immunol, 2016, 16: 407-420.
[8] Broz P. Recognition of Intracellular Bacteria by Inflammasomes. Microbiol Spectr, 2019, 7.
[9] Swanson KV, Deng M, Ting JP. The NLRP3 inflammasome: molecular activation and regulation to therapeutics. Nat Rev Immunol, 2019, 19: 477-489.
[10] Jo EK, Kim J K, Shin DM, et al. Molecular mechanisms regulating NLRP3 inflammasome activation. Cell Mol Immunol, 2016, 13: 148-159.
[11] Yang J, Zhao Y, Shao F. Non-canonical activation of inflammatory caspases by cytosolic LPS in innate immunity. Curr Opin Immunol, 2015, 32: 78-83.
[12] Kayagaki N, Stowe I B, Lee BL, et al. Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling. Nature, 2015, 526: 666-671.
[13] Kayagaki N, Wong MT, Stowe IB, et al. Noncanonical inflammasome activation by intracellular LPS independent of TLR4. Science, 2013, 341: 1246-1249.
[14] Li H, Zhao XK, Cheng YJ, et al. Gasdermin D-mediated hepatocyte pyroptosis expands inflammatory responses that aggravate acute liver failure by upregulating monocyte chemotactic protein 1/CC chemokine receptor-2 to recruit macrophages. World J Gastroenterol, 2019, 25: 6527-6540.
[15] Chen YL, Xu G, Liang X, et al. Inhibition of hepatic cells pyroptosis attenuates CLP-induced acute liver injury. Am J Transl Res, 2016, 8: 5685-5695.
[16] Zhong Y, Lu Y, Yang X, et al. The roles of NLRP3 inflammasome in bacterial infection. Mol Immunol, 2020, 122: 80-88.
[17] Deng M, Tang Y, Li W, et al. The Endotoxin Delivery Protein HMGB1 Mediates Caspase-11-Dependent Lethality in Sepsis. Immunity, 2018, 49: 740-753.e747.
[18] Krenkel O, Tacke F. Liver macrophages in tissue homeostasis and disease. Nat Rev Immunol, 2017, 17: 306-321.
[19] Yu X, Lan P, Hou X, et al. HBV inhibits LPS-induced NLRP3 inflammasome activation and IL-1β production via suppressing the NF-κB pathway and ROS production. J Hepatol, 2017, 66: 693-702.
[20] Chen N, Ou Z, Zhang W, et al. Cathepsin B regulates non-canonical NLRP3 inflammasome pathway by modulating activation of caspase-11 in Kupffer cells. Cell prolif, 2018, 51: e12487.
[21] Tsuchida T, Friedman SL. Mechanisms of hepatic stellate cell activation. Nat Rev Gastroenterol Hepatol, 2017, 14: 397-411.
[22] Koch A, Horn A, Dückers H, et al. Increased liver stiffness denotes hepatic dysfunction and mortality risk in critically ill non-cirrhotic patients at a medical ICU. Crit Care, 2011, 15: R266.
[23] Gonnert FA, Kunisch E, Gajda M, et al. Hepatic Fibrosis in a Long-term Murine Model of Sepsis. Shock, 2012, 37: 399-407.
[24] Wree A, Eguchi A, Mcgeough M D, et al. NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice. Hepatology, 2014, 59: 898-910.
[25] Pai MH, Wu JM, Yang PJ, et al. Antecedent Dietary Glutamine Supplementation Benefits Modulation of Liver Pyroptosis in Mice with Polymicrobial Sepsis. Nutrients, 2020, 12.
[26] Xu Z, Mu S, Liao X, et al. Estrogen protects against liver damage in sepsis through inhibiting oxidative stress mediated activation of pyroptosis signaling pathway. PLoS One, 2020, 15: e0239659.
[27] Zhang GX, Du YJ, Li XH, et al. Protective effect of erythropoietin against lipopolysaccharide induced inflammation and mitochondrial damage in liver. J Biol Regul Homeost Agents, 2018, 32: 199-206.
[28] Wang T, Zhong H, Zhang W, et al. STAT5a induces endotoxin tolerance by alleviating pyroptosis in kupffer cells. Mol Immunol, 2020, 122: 28-37.
[29] Liu J, Du S, Kong Q, et al. HSPA12A attenuates lipopolysaccharide-induced liver injury through inhibiting caspase-11-mediated hepatocyte pyroptosis via PGC-1alpha-dependent acyloxyacyl hydrolase expression. Cell Death Differ, 2020, 27: 2651-2667.
[30] Liu Y, Jing YY, Zeng CY, et al. Scutellarin Suppresses NLRP3 Inflammasome Activation in Macrophages and Protects Mice against Bacterial Sepsis. Front Pharmacol, 2017, 8: 975.
[31] Hong M K, Hu LL, Zhang YX, et al. 6-Gingerol ameliorates sepsis-induced liver injury through the Nrf2 pathway. Int Immunopharmacol, 2020, 80: 106196. |
