Abstract: Objective To analyze the clinical and imaging features of gallbladder carcinoma and to improve the diagnostic level.Methods The clinical and imaging data of 89 patients with gallbladder diseases diagnosed and treated in our hospital were retrospectively analyzed, including 34 cases of gallbladder carcinoma and 55 cases of benign gallbladder lesions. The serological indexes and imaging characteristics were compared between the 2 groups.Results Serological indexes including carbohydrate antigen 12-5 (CA12-5) (P=0.03), carbohydrate antigen 19-9 (CA19-9) (P=0.04), lactate dehydrogenase (P<0.01) and carcinoembryonic antigen (CEA) (P=0.00) were statistically different between benign and malignant gallbladder diseases. As for imaging characteristics, gallbladder lesion classification (P<0.01), lesion thickness (P=0.01), arterial phase enhancement amplitude (P<0.01), mucosal line integrity (P=0.03), enlarged lymph nodes (P=0.00), biliary obstruction (P=0.02) and apparent diffusion coefficient (ADC) value (P<0.01) were significantly different. Binary logistic regression analysis showed that there were significant differences in the mucosal line integrity (OR=345.35), biliary obstruction (OR=282.43) and ADC value (OR=0.001) between benign and malignant gallbladder diseases.Conclusion The integrity of mucosal line, biliary obstruction and ADC value are valuable in the diagnosis of gallbladder carcinoma, with better diagnostic efficiency combined with the levels of serum CA12-5, CA19-9, lactate dehydrogenase and CEA.

Key words: Gallbladder carcinoma, Granuloma, Computed tomography, Magnetic resonance imaging, Serology