Investigation on medication adherence and quality of life of liver transplant recipients in a hospital in Shanghai during the outbreak of novel coronavirus pneumonia

Abstract

Abstract: Objective To investigate the medication adherence and quality of life in adult liver transplant (LT) recipients during the epidemic of 2019 novel coronavirus pneumonia (COVID-19) in China and to provide guidance for health management of LT recipients in the face of public health emergencies.Methods A cross-sectional survey was conducted among 183 cases of adult LT recipients followed up in our hospital from 17th to 21st February 2020. The questionnaire consisted of self-designed general data questionnaire, the Basel Assessment of Adherence Immunosuppressive Medications Scale (BAASIS) and post-liver transplant quality of life (pLTQ). The data was analyzed to investigate the medication adherence and quality of life of LT recipients during the COVID-19 pandemic, and the influencing factors were analyzed by multiple linear regression analysis.Results One hundred and eighty samples were included in the analysis. ① The BAASIS score of medication adherence was (5.25 ± 2.26) points, and the pLTQ score of quality of life was (146.51 ± 29.73) point. Among all the recipients, 57.22% were with good medication adherence.② The independent influencing factors of the medication adherence in LT recipients included “unemployment after surgery” (b'=-0.192, P=0.008), “long survival time” (b'=0.188, P=0.009), and “minority nationality” (b'=0.186, P=0.010). ③ The independent influencing factors of life quality in LT recipients included “poor sleep quality” (b'=-0.252, P=0.000), “high monthly per capita income” (b'=0.212, P=0.003), “long survival time” (b'=0.177, P=0.009), and “unemployment after the surgery” (b'=-0.150, P=0.036).Conclusion The medication adherence of LT recipients was better during the COVID-19 pandemic than normal period, and the quality of life was not significantly affected. However, employment after operation, long survival time and minority nationality played negative effects on patients’ medication adherence. And poor sleep quality, low income, short survival time, and unemployment after operation played negative effects on patients’ quality of life. Patients with these features need more attention, targeted guidance and nursing intervention.

Key words: Novel coronavirus pneumonia, Liver transplant, Medication adherence, Quality of life, Influencing factors

JIA Li-yan, JING Yi-lei, ZHANG Qian, LV Xiao-ying, WU Xin-rui, MA Fang-hui, LIU Wen-qiong, XUE Feng, ZHU Yan-bo. Investigation on medication adherence and quality of life of liver transplant recipients in a hospital in Shanghai during the outbreak of novel coronavirus pneumonia[J]. Chinese Hepatolgy, 2021, 26(6): 655-660.

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