Abstract: Objective To investigate the relationship between 3-year survival rate after radical resection and Barcelona Clinic Liver Cancer (BCLC) Kinki stage.in patients with primary liver cancer (PLC). Methods The clinical data of 99 PLC patients underwent open liver resection from April 2016 to April 2018 were retrospectively analyzed. The patients were divided into good prognosis group (n = 64, survival) and poor prognosis group (n = 35, death) according to their 3-year survival condition. The baseline data of the 2 groups including gender, age, residence, ethnicity, tumor diameter, tumor number, tumor site, hepatitis history, family history, Child-Pugh grade, TNM stage, differentiation degree, and BCLC Kinki stage were collected and analyzed. The differences between the 2 groups were analyzed by multivariate logistic regression analysis and the risk factors affecting the prognosis were determined. The patients were followed up for 3 years, and the 3-year survival rates among the paients with different BCLC Kinki stage were compared. Results In poor prognosis group, the number of patients with tumor diameter > 5cm was 30 (85.71%), and the number of patients with tumor diameter ≤ 5 cm was 5 (14.29%). In good prognosis group, the number of patients with tumor diameter > 5 cm was 38 (59.38%), and the number of patients with tumor diameter ≤ 5 cm was 26 (40.63%). The difference was statistically significant (χ²=18.723, P<0.05). There were 13 Child-Pugh grade A cases (37.14%) and 22 Child-Pugh grade B cases (62.86%) in poor prognosis group. There were 40 Child-Pugh grade A cases (62.50%) and 24 Child-Pugh grade B cases (37.50%) in good prognosis group. The difference was statistically significant (χ²=5.849, P<0.05). In poor prognosis group, there were 10 TNM stage I or II cases (28.57%) and 25 TNM stage III or IV cases (71.43%). In good prognosis group, there were 38 TNM stage I or II cases (59.38%) and 26 TNM stage III or IV cases (40.62%), the difference was statistically significant (χ²=8.597, P<0.05). In poor prognosis group, there were 24 cases with poorly differentiated tumors (68.57%) and 11 cases with moderately or highly differentiated (31.43%), while in good prognosis group, there were 14 cases with poorly differentiated tumors (21.88%) and 50 cases with moderately or highly differentiated (78.12%), the difference was statistically significant (χ²=20.861, P<0.05). In poor prognosis group, there were 9 cases in BCLC Kinki B1 stage (25.71%) and 26 cases in BCLC Kinki B2 stage (74.29%). In good prognosis group, there were 39 cases in BCLC Kinki B1 stage (60.94%) and 25 cases in BCLC Kinki B2 stage (39.06%). The difference was statistically significant (χ²=11.239, P<0.05). Multivariate Logistic regression analysis confirmed that tumor diameter > 5 cm, Child-Pugh grade B, TNM stage Ⅲ or IV stage, low differentiation degree, BCLC Kinki B2 stage were risk factors affecting the prognosis of patients with PLC after radical resection, all with P<0.05. The 3-year survival rates of BCLC Kinki stage B1 and stage B2 patients were 60.94% and 39.06%, respectively, and the 3-year survival rates of patients with different BCLC Kinki stage were significantly different (P<0.05). Conclusion The survival rates of patients with PLC after radical resection are affected by tumor diameter, Child-Pugh grade, TNM stage, differentiation degree, and BCLC Kinki stage. Compared to BCLC Kinki stage B2 patients, the survival rates of BCLC Kinki stage B1 patients are higher.

Key words: Primary liver cancer, Kinki stage, Radical resection, Prognosis, Risk factor, Survival rate