Application of gadolinium selenite disodium enhanced MRI in risk assessment of highly dysplastic nodules transforming into blood rich hepatocellular carcinoma

Abstract

Abstract: Objective To study the application of Gd-EOB-DTPA enhanced magnetic resonance imaging (MRI) in risk assessment of highly dysplastic nodules (HGDN) transforming into blood rich hepatocellular carcinoma (HCC). Methods The clinical data of 72 patients with hgdn diagnosed in our hospital from August 2015 to August 2019 were retrospectively collected. According to the occurrence of hypervascular HCC after follow-up, they were divided into hgdn group (n = 39) and HCC group (n = 33),GD EOB DTPA enhanced MRI was detected at the first admission in both groups, and the number and diameter of nodules were recorded. The axial T1 weighted imaging (T1WI), axial T2 weighted imaging (T2WI), diffusion weighted imaging (DWI), high, equal and low signal of hepatobiliary phase and arteriovenous phase relative to normal liver parenchyma were analyzed Kappa test was used to analyze the sensitivity, specificity and accuracy of GD EOB DTPA enhanced MRI in the diagnosis of hypervascular HCC. Results The incidence of hgdn transformed and blood rich HCC was 45.83% (33/72), and the detection rate of focal nodules in HCC patients was 44.35% (51/114).The proportion of patients with high signal T1WI, low signal T2WI, high signal hepatobiliary stage and isolow signal DWI in hgdn group was significantly higher than that in HCC group (65.08% vs 37.25%, 57.14% vs31.37%, 77.78% vs 11.76%, 74.60% vs23.53%), and the proportion of patients with arterial enhancement and portal vein clearance was significantly lower than that of HCC group (34.92% vs 54.90%, 28.57% vs 49.02%), and the difference was statistically significant (P < 0.05).The sensitivity, specificity, accuracy and kappa value of GD EOB DTPA enhanced MRI were 87.88%, 84.62%, 86.11% and 0.722 respectively. Conclusion GD EOB DTPA enhanced MRI has high value in the risk assessment of hgdn transforming into blood rich HCC, which is worthy of clinical promotion.
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Key words: Gadolinium selenate disodium, Nuclear magnetic resonance, Highly dysplastic nodules, Hepatocellular carcinoma, Hypervascular transformation

FAN Heng-liang, ZHANG Wei, XU Ya-chun. Application of gadolinium selenite disodium enhanced MRI in risk assessment of highly dysplastic nodules transforming into blood rich hepatocellular carcinoma[J]. Chinese Hepatolgy, 2021, 26(12): 1332-1335.

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