Abstract: Objective To analyze the changes of serum complement 3 (C3), complement 4 (C4) and immunoglobin G (IgG) levels in patients with chronic hepatitis B (CHB) and liver cirrhosis and their clinical significance. Methods One hundred and sixteen patients with CHB admitted from March 2018 to December 2019 were selected as the observation group and 116 healthy persons who underwent physical examination at the same period of time were enrolled as the control group. The serum levels of C3, C4 and IgG were detected in both groups of people, and the correlation between the levels of C3, C4 and IgG and the grades and stages of liver histopathology in the observation group were analyzed. Results The levels of C3[(0.84±0.12)g/L] and C4[(0.23±0.05)g/L] of the observation group were lower than those of the control group [C3:(1.07±0.21)g/L] [C4:(0.31) ±0.06)g/L], while the serum IgG [(27.59±6.27)mg/L] level of the observation group was higher than that of the control group [(16.81±3.15)mg/L] (P<0.05). The levels of C3 and C4 in patients with G2-G4 grades of inflammation in the observation group were significantly lower than those in patients with grade G1 (F=4.142, P<0.05; F=4.142, P<0.05). In the observation group, the levels of complement C3 and C4 in patients with grades of S2-S4 inflammation were significantly lower than those in patients with grade S1 (F=8.512, P<0.05). The grades of≥G2 and G4 were negatively correlated with complement C3 and C4, and positively correlated with IgG levels (r=0.572, P=0.014; r=0.589, P=0.009). The grades of ≥S2 and S4 were negatively correlated with C3, C4, whereas positive correlated with IgG (r=0.631, P=0.007; r=0.551, P=0.007). Conclusion There is a certain correlation between serum C3, C4 and IgG levels and the severity of liver cirrhosis in CHB patients, which has significance for the diagnosis, treatment and prognostic evaluation of patients with CHB.

Key words: Chronic hepatitis B, Liver cirrhosis, Complement 3, Complement 4, Immunoglobin G