The value of left ventricular PSD using ultrasond in cirrhosis with different Child-Pugh grading

Abstract

Abstract: Objective To investigate the expression level and clinical value of left ventricular peak strain dispersion (PSD) in cirrhosis patients with different Child-Pugh grading. Methods One hundred and sixteen patients with liver cirrhosis admitted to our hospital from October 2018 to October 2020 were enrolled, all of them underwent ultrasound examination. The PSD value and liver function indexes were recorded, and the unconditional logistic analysis was used to analyze the relationship between Child-Pugh grading and PSD. Results Among the 116 patients, 42 cases were Child-Pugh grade A, with PSD as (40.4 ± 8.2) ms and the course of disease as (2.6 ± 0.7) years; 48 cases were grade B, with PSD as (52.8 ± 5.3) ms and the course of disease as (3.7 ± 1.1) years; 26 cases were grade C, with PSD as (58.7 ± 6.6)ms and the course of disease as (4.8 ± 0.9) years. PSD and the course of disease among patients with different Child-Pugh grading were compared with significant differences (P<0.05). The serum CA125 levels of patients with Child-Pugh A, B, C were [(80.8 ± 25.4) U/mL, (193.7 ± 52.0) U/m, (250.6 ± 71.1) U/mL], the serum-ascites albumin gradient (SAAG) levels of patients with Child-Pugh A, B, C were [(14.0 ± 3.8)g/L, (17.9 ± 3.6)g/L, (22.3 ± 4.4)g/L], with significant differences (P<0.05). The unconditional logistic regression analysis showed that the serum CA125 (95%CI=1.071-2.478, OR=1.629, P=0.023), SAAG (95%CI=1.328-3.242, OR=2.075, P=0.001) and PSD (95%CI=1.334-5.665, OR=2.749, P=0.006) were risk factors for decompensated cirrhosis. The PSD (95%CI=1.102-2.399, OR=1.626, P=0.014) was a risk factor for Child-Pugh C in patients with cirrhosis. The receiver operator characteristic (ROC) curve showed that the area under the curve (AUC) of PSD in predicting the Child-Pugh C was 0.752 (SE=0.074, 95%CI=0.608-0.896, P=0.007), the sensitivity was 0.846, and the specificity was 0.550. Conclusion The PSD is closely related to Child-Pugh grading of patients with cirrhosis. PSD is helpful to evaluate the liver function, which might provide guidance for clinical interference.

Key words: Ultrasound, Child-Pugh grading, Cirrhosis, Left ventricular peak strain dispersion

WANG Xue-wei, HUANG Xiao-yun, PANG Chang-xu, QIAO Chao-feng, LI Cai-xia. The value of left ventricular PSD using ultrasond in cirrhosis with different Child-Pugh grading[J]. Chinese Hepatolgy, 2022, 27(2): 174-177.

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