Abstract: Objective To investigate the clinical effect of embolization with polyvinyl alcohol-loaded microspheres for liver metastases from colon cancer. Methods Eighty-six patients with liver metastases from colon cancer who were admitted from January 2020 to January 2021 were selected as the study subjects. They were divided into a control group and an experimental group by random number method, each with 43 cases. The control group was treated with traditional embolization therapy (lipiodol in combination with epirubicin), and the experimental group was treated with new embolization therapy (polyvinyl alcohol drug-loaded microspheres in combination with epirubicin). Liver function levels, tumor necrosis rate, clinical efficacy, and adverse reactions were compared between these two groups of patients after treatment. Results The disease remission rate and disease control rate of the experimental group were 79.07% (34/43) and 95.35% (41/43), respectively. The disease remission rate and disease control rate of the control group were 51.16% (22/43) and 88.37% (38/43), respectively. The disease remission rate and tumor necrosis rate of the experimental group were significantly higher than those of the control group (P<0.05). The levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and albumin (Alb) in the experimental group were (35.39±7.65) U/L, (36.87±7.68) U/L, and (38.21±7.54) g/L, respectively. The levels of ALT, AST and Alb in the control group were (48.14±10.36) U/L, (50.24±11.54) U/L, and (31.24±6.47) g/L, respectively. The levels of ALT and AST in the test group were significantly lower than those in the control group, and the Alb levels in the test group were significantly higher than those in the control group (P<0.05). The incidence of gastrointestinal reactions, abdominal pain, and fever in the test group were significantly lower than those in the control group (P<0.05). Conclusion Interventional embolization with polyvinyl alcohol-loaded microspheres for liver metastases from colon cancer can effectively increase tumor necrosis rate, disease remission rate, protect liver function, and reduce adverse reactions.

Key words: Polyvinyl alcohol drug-loaded microspheres, Interventional embolization, Colon cancer liver metastasis