Abstract: Objective To analyze and evaluate the efficacy and feasibility of ETV with TDF in the treatment of low-level viremia (LLV) chronic hepatitis B patients with NAS. Methods The patients with HBV DNA less than 500 IU/ml were treated with nucleoside (acid) analogues (NAs) for at least 48 weeks. The patients with high sensitive detection value between 20 IU/ml and 2000 IU/ml were selected as the research objects. On the basis of necessary conventional treatment, the patients were treated with ETV 0.5 mg, qN, TDF 300 mg, qd for antiviral therapy. Results With the extension of treatment time, the virological response rate of patients in this group was improved. The complete response rate was 64.3% (18/28) at 48W, and the total response rate was 96.4% (27/28). There was no significant difference between the two groups (P>0.05). Conclusion The quantitative detection of high sensitivity HBV DNA can realize the diagnosis of LLV in patients with chronic hepatitis B. The effect of ETV combined with TDF in the treatment of NAs in patients with chronic hepatitis B is good with less adverse reactions, which is worthy of clinical application.

Key words: Chronic hepatitis B, Low-level viremia, Treatment