Abstract: Objective To investigate the relationship between intrahepatic cholestasis of pregnancy (ICP) and fetal growth restriction and adverse pregnancy outcomes. Methods The clinical data of 72 ICP puerperants treated in our hospital from May 2018 to May 2021 were analyzed retrospectively. According to the severity of ICP, 72 ICP puerperants were divided into mild group(n=42) and severe group(n=30) In addition, 30 normal puerperants examined in our hospital were selected as control group; Fetal growth restriction and adverse pregnancy outcomes were compared among the three groups,In addition, according to the adverse pregnancy outcomes of ICP puerperants, they were divided into good group (n=41) and bad group (n=31). The difference of clinical characteristics between the two groups was observed, and the risk factors of adverse pregnancy outcome were analyzed by logistic regression analysis model. Results The total incidence of fetal growth restriction and adverse pregnancy outcomes in the three groups were compared[33.33%(14/42) vs 56.67%(17/30) vs 10.00%(3/30)], and the difference was statistically significant (P<0.05).The proportion of pregnant puerperants with age ≥ 35 years old, severe ICP, diabetes mellitus in pregnancy and abnormal placental pathology was significantly higher than that in the good group[70.97%(22/31) vs 41.46% (17/41), 54.84% (17/31) vs 31.71% (13/41), 61.29% (19/31) vs 34.15% (14/41), 70.97% (22/31) vs 36.59 (15/41)] (P<0.05).Logistic regression analysis showed that age ≥ 35 years old(OR:4.267,95%CI:1.114-16.344), severe ICP(OR:3.398,95%CI:1.235-9.349), diabetes mellitus in pregnancy(OR:4.217,95%CI:1.182-15.045) and abnormal placenta pathology(OR:3.954,95%CI:1.156-13.524) were the risk factors for poor prognosis of ICP puerperants. Conclusion Severe ICP can significantly increase the incidence of fetal growth restriction and adverse pregnancy outcomes. In addition, elderly puerperants, gestational diabetes mellitus and abnormal placental pathology are risk factors for adverse pregnancy outcomes.

Key words: Intrahepatic cholestasis of pregnancy, Fetal growth restriction, Pregnancy outcome