[1] World Health Organization. Global status report on alcohol and health 2018. http://www.who.int/publications/i/item/9789241565639 [2] Gao B, Bataller R. Alcoholic liver disease: pathogenesis and new therapeutic targets. Gastroenterology,2011,141:1572-1585. [3] Wilfred de Alwis NM, Day CP. Genetics of alcoholic liver disease and nonalcoholic fatty liver disease. Semin Liver Dis,2007,27:44-54. [4] Buch S, Stickel F, Trépo E, et al. A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis. Nat Genet, 2015,47:1443-1448. [5] Stickel F, Hampe J. Genetic determinants of alcoholic liver disease. Gut,2012,61:150-159. [6] Verhulst B, Neale MC, Kendler KS. The heritability of alcohol use disorders: a meta-analysis of twin and adoption studies. Psychol Med,2015,45:1061-1072. [7] Kim KY, Kim JO, Kim YS, et al. Genome-wide association of individual vulnerability with alcohol-associated liver disease: A Korean genome and epidemiology study. Hepatology, 2022,75:391-402. [8] Kim Y, Han BG. Cohort Profile: The Korean Genome and Epidemiology Study (KoGES) Consortium. Int J Epidemiol,2017,46:1350. [9] Edenberg HJ, McClintick JN. Alcohol Dehydrogenases, Aldehyde Dehydrogenases, and Alcohol Use Disorders: A Critical Review. Alcohol Clin Exp Res,2018,42:2281-2297. [10] He L, Deng T, Luo HS. Genetic polymorphism in alcohol dehydrogenase 2 (ADH2) gene and alcoholic liver cirrhosis risk. Int J Clin Exp Med, 2015,8:7786-7793. [11] Piao YF, Li JT, Shi Y. Relationship between genetic polymorphism of cytochrome P450IIE1 and fatty liver. World J Gastroenterol,2003,9:2612-2615. [12] J?rvel?inen HA, Orpana A, Perola M, et al. Promoter polymorphism of the CD14 endotoxin receptor gene as a risk factor for alcoholic liver disease. Hepatology, 2001,33:1148-53. [13] Zhao YY, Xiao M, Zhang CL, et al. Associations between the tumor necrosis factor-α gene and interleukin-10 gene polymorphisms and risk of alcoholic liver disease: A meta-analysis. Clin Res Hepatol Gastroenterol,2016,40:428-439. [14] Goltz D, Hittetiya K, Vössing LM, et al. A?-antitrypsin PiMZ heterozygosity has an independent aggravating effect on liver fibrosis in alcoholic liver disease. Virchows Arch, 2014,465:539-546. [15] Barabási AL. Network medicine--from obesity to the "diseasome". N Engl J Med, 2007,357:404-407. |