Abstract: Objective To compare the efficacy of endoscopic variceal ligation (EVL) and EVL+ endoscopic injection sclerotherapy (EIS) in the treatment for esophageal variceal bleeding (EVB) in patients with liver cirrhosis.Methods The clinical date of 82 cirrhotic patients with EVB admitted to our hospital from January 2010 to January 2018 were collected. They were divided into group A (EVL group, 42 cases) and group B (EVL + EIS group, 40 cases) according to the therapeutic methods. The treatment effect of the two groups were evaluated. The frequency of EVL and complications of the 2 groups were recorded. Patients were followed up for 1 year. The total effective rate, rebleeding rate and other indicators were recorded.Results 1.The total effective rate of group B was 95.0﹪, which was significantly higher than that of group A (59.5﹪) (χ²=10.82,P=0.012); 2. The average frequency of EVL in group B was significantly fewer than that in group A (2.5 vs 6.5, χ²=12.78, P=0.0085); 3. There was no significant difference of complications rates during treatment and 1-year followup between the 2 groups (P>0.05); 4. The rebleeding rates at 2 weeks after operation of group A and B were 8.51% and 4.98%, respectively, and there was no significant difference (χ²=0.947, P=0.25). However, with continuous follow-up at 1 month, 3 months, 6 months, 9 months, and 12 months after operation, the rebleeding rate in group A was 42.5%, which was significantly higher than that in group B. The difference was statistically significant (χ²=14.66, P=0.004).Conclusion Compared with EVL alone, EVL + EIS has a higher total treatment effect, a lower rebleeding rate, a fewer average frequency of EVL treatments, and the incidence of complication is not increased. It is worth clinical promotion.

Key words: Endoscopic variceal ligation, Endoscopic injection sclerotherapy, Sequential therapy, Lauromacrogol