Abstract: Objective To evaluate the clinical and treatment characteristics of patients with Primary Biliary Cholangitis (PBC), which can provide important evidence for prevention and control of PBC.Methods We retrospective analysed 43 PBC patients treated in Union Hospital Affiliated to Fujian Medical University from November 2012 to February 2019, evaluated and summarized their clinical characteristics and treatment outcomes.Results Middle and elderly aged women were at high incidence of PBC, the incidence rate between men and women was 1:9.75. Common symptoms were fatigue, abdominal discomfort and skin itching. PBC could be combined with multiple diseases, such as hyperlipidemia (14 cases, 32.6%), cholecystitis with or without gallstone (11 cases, 25.6%) and osteoporosis (3 cases, 7.0%). After treated with ursodeoxycholic acid, γ-glutamyl transpeptadase and alkaline phosphatase decreased significantly, especially in decompensated group (GGT: 372.23±285.13, 148.20±141.91, t=3.686, P=0.002; ALP: 361.34±245.10, 183.27±115.17, t=3.252, P=0.005). While total bilirubin and direct bilirubin increased significantly in decompensated group (TBIL: 42.93±27.41, 123.49±127.21, t=2.612, P=0.019; DBIL: 25.51±19.88, 70.21±78.52, t=2.547, P=0.023).Conclusion The early symptoms of PBC was not obvious. Therefore, more attention should be paid to the prevention and treatment of the PBC.

Key words: Primary biliary cholangitis, Clinical Characteristics, Treatment outcomes