Correlational research of Gensini score and coronary atherosclerotic disease complicated with nonalcoholic fatty liver disease

Abstract

Abstract: Objective To explore the relationship between nonalcoholic fatty liver disease (NAFLD) and Gensini score in patients with coronary atherosclerotic disease (CAD).Methods 340 CAD patients hospitalized from January 2018 to December 2021 were collected, including 252 males and 88 females in Meizhou People’s Hospital, with an average age of (58.3 ± 9.2) years. 340 CAD patients were divided into 164 cases of CAD combined with NAFLD (NAFLD group) and 176 cases of simple CAD (non-NAFLD group). The diagnosis of CAD and NAFLD met the requirements. The clinical data of NAFLD group and non-NAFLD group were compared, and the results of Gensini score of liver histological features in NAFLD group were analyzed.Results The age, body mass index (BMI) of NAFLD group were (57.4 ± 9.6) years old, (24.8 ± 3.4) kg/m², which were significantly different with non-NAFLD group [(59.0 ± 9.1) years old, (27.2 ± 3.1) kg/m², P<0.05]. The waist circumference of NAFLD group was (96.5 ± 9.1)cm, which was significantly higher than that of non-NAFLD group [(84.6 ± 9.5) cm, P<0.05]. High-density lipoprotein (HDL) and triglyceride (TG) in NALFD group were (0.9 ± 0.2) mmol/l and (1.8±0.5) mmol/l, which were significantly different from those in non-NAFLD group [(1.1 ± 0.2) mmol/l and (1.6 ± 0.4) mmol/l] (P<0.05). In addition, Gensini score of NAFLD group was (56.9 ± 9.1) points, significantly higher than that of non-NAFLD group [(48.2 ± 8.2) points, P<0.05]. The mild, moderate and severe degree of coronary artery lesions in NAFLD group were 32 cases (19.5%), 21 cases (12.8%) and 111 cases (67.7%), while those in non-NAFLD group were 55 cases (31.2%), 38 cases (21.6%) and 83 cases (47.1%), the difference was statistically significant. In 64 CAD patients with NAFLD, the degree of hepatic steatosis was 20 cases in S0 grade, 57 cases in S1 grade, 64 cases in S2 grade and 23 cases in S3 grade. Gensini scores of each degree of hepatic steatosis were (10.5 ± 1.3) points, (34.4 ± 4.2) points, (65.9 ± 8.0) points and (130.8 ± 15.7) points, respectively.Conclusion Gensini scores of patients with CAD and NAFLD of different degrees of liver steatosis are significantly different, and Gensini scores are helpful to quantitatively evaluate the degree of liver steatosis of patients.

Key words: Coronary atherosclerotic heart disease, Nonalcoholic fatty liver disease, Gensini score

ZHANG Qi-feng, MIAO lei-ming, ZHONG Fang-ming, HE Xue-bo, HUANG Jun-ping. Correlational research of Gensini score and coronary atherosclerotic disease complicated with nonalcoholic fatty liver disease[J]. Chinese Hepatolgy, 2022, 27(12): 1314-1317.

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