Abstract: Objective To investigate the clinical features of primary liver cancer associated with Wilson's disease (WD). Methods Patients with primary liver cancer admitted to our hospital were retrospectively enrolled. The clinical manifestations, laboratory tests, diagnosis and treatments were collected. Results Among the 12 patients with primary liver cancer associated with WD, 5 cases were males and 7 were females. All cases were combined with liver cirrhosis, 8 cases were Child-Pugh B/C. Four patients with alpha fetoprotein (AFP) negative, while 8 patients with AFP positive. There were 4 cases in BCLC stage A, 1 case in stage B, 4 cases in stage C and 3 cases in stage D. One patients received conservative treatment, 5 patients treated by transcatheter arterial chemoembolization (TACE), 2 patients received TACE combined with ablation and 4 patients received liver transplantation. Conclusion WD-associated primary liver cancer is rare clinically, and most of them are in middle or late BCLC stage. The occurrence of liver cancer should be closely followed up in patients with WD-associated cirrhosis, in order to improve the early diagnosis rate.

Key words: Wilson's disease, Primary liver cancer, Diagnosis, Treatment